Difference between revisions of "Deep brain stimulation"

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===Parkinson's disease===
 
===Parkinson's disease===
  
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Parkinson's disease is the neurodegenerative disease, which is caused by loss of neurons in the substantia nigra pars compacta. These neurons produce dopamine, therefore patients suffer from the loss of dopamine. It causes tremor, postural instability and bradykinesia. Patients could be treated by levodopa or other dopaminergic drugs but these drugs have side effects in the long-term use and tend to loss their efficiency.<ref name="best medical therapy">WILLIAMS, Adrian et al. Deep brain stimulation plus best medical therapy versus best medical therapy alone for advanced Parkinson’s disease(PD SURG trial): a randomised, open-label trial. Lancet Neurology. 2010, 9(6), 581–91. Doi: 10.1016/S1474-4422(10)70093-4 Available online at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2874872/ (Retrieved 19th April, 2017).</ref> The accuracy of diagnosis of Parkinson's disease is low, thus deep brain stimulation is appropriate only for those patients, which suffer from it for more than 5 years, in order to assure that they really suffers from Parkinson's disease. Therefore, deep brain stimulation is mainly used among patients, whose medication cannot sufficiently handle with the symptoms of Parkinson's disease and the diagnosis of the disease was confirmed.<ref name="Alzforum1"/> However, each candidate for DBS as a treatment of Parkonson's disease has to be reviewed carefully by the doctor, in order to decide that the treatment is appropriate to him or her.<ref name="DBS springer"/> As a treatment of Parkinson's disease is usually used the stimulation of one of these three areas of brain: the thalamus, globus pallidus pars interna (GPi), or subthalamic nucleus (SNT), but the stimulation of SNT is preferred at present.<ref name="best medical therapy"/> Breit and his colleagues claim that recently DBS turned to be the most frequently used surgical therapy for movement disorders.<ref name="DBS springer"/>   
+
Parkinson's disease is the neurodegenerative disease, which is caused by loss of neurons in the substantia nigra pars compacta. These neurons produce dopamine, therefore patients suffer from the loss of dopamine. It causes tremor, postural instability and bradykinesia. Patients could be treated by levodopa or other dopaminergic drugs but these drugs have side effects in the long-term use and tend to loss their efficiency.<ref name="best medical therapy">WILLIAMS, Adrian et al. Deep brain stimulation plus best medical therapy versus best medical therapy alone for advanced Parkinson’s disease(PD SURG trial): a randomised, open-label trial. Lancet Neurology. 2010, 9(6), 581–91. Doi: 10.1016/S1474-4422(10)70093-4 Available online at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2874872/ (Retrieved 19th April, 2017).</ref> The accuracy of diagnosis of Parkinson's disease is low, thus deep brain stimulation is appropriate only for those patients, which suffer from it for more than 5 years, in order to assure that they really suffers from Parkinson's disease. Therefore, deep brain stimulation is mainly used among patients, whose medication cannot sufficiently handle with the symptoms of Parkinson's disease and the diagnosis of the disease was confirmed.<ref name="Alzforum1"/> However, each candidate for DBS as a treatment of Parkonson's disease has to be reviewed carefully by the doctor, in order to decide that the treatment is appropriate and cost-efficient for him or her.<ref name="DBS springer"/> As a treatment of Parkinson's disease is usually used the stimulation of one of these three areas of brain: the thalamus, globus pallidus pars interna (GPi), or subthalamic nucleus (SNT), but the stimulation of SNT is preferred at present.<ref name="best medical therapy"/> Breit and his colleagues claim that recently DBS turned to be the most frequently used surgical therapy for movement disorders.<ref name="DBS springer"/>   
  
 
===Essential tremor===
 
===Essential tremor===

Revision as of 12:36, 20 April 2017

Deep Brain Stimulation of Parkinson's Disease

List of Deep brain stimulation devices:

Deep brain stimulation (DBS) is a neurosurgical technique in which electrodes are implanted into patient's brain. Although, patients have to undergo an invasive surgery, it is growing field of neurosurgery.[1] DBS proved to be cost-effective in a treatment of certain severe neurological diseases as Parkinson's disease, essential tremor, dystonia, obsessive-compulsive disorder (OCD) or epilepsy.[2] The treatment of other neurological and psychiatric diseases as depression or chronic pain is examined intensively.[1]

DBS is not a cure. None of the diseases to which is used are curable at the moment. It could however, eliminate symptoms of the diseases, which negatively affected the lives of the patients.[3] DBS is used in medical devices, which are on prescription, the use for cognitive enhancement is highly limited. However, certain cases of possible cognitive enhancement were also reported.[4]

Main Characteristics

RNS System for the treatment of epilepsy

Deep brain stimulation consists in stimulation of a brain by the electrodes, which are implanted in the brain. The electrodes are often referred as leads and are linked with pulse generator via wires. The different diseases could be treated with one device, since the output of the treatment is dependant at the position of electrodes.[5] The pulse generator could be rechargeable or non-rechargeable[6] and could be implanted in the chest[7] or under the scalp[8]. The precise function of the pulse generator is adjusted by the programmer.[5]

The surgery usually consists of two procedures. Firstly, the electrodes are implanted into patient's brain. Patient's head is fixed in a stereotactic head frame, which avoids any movement during the surgery. The patient has to be awake in order to surgeons could see the impact of the stimulation.[5] There are several electronic devices, which could help surgeons to reach the correct spot in the brain.[9] Since DBS does not require a destruction of any area in the brain, it is reversible procedure.[10] A few days later, surgeons could implant the pulse generator.[5] The patients have to visit their doctors several time after the surgery to program correctly their pulse generator. The pulse generators could deliver a various voltage and frequency and usually just a particular programme has the best effect on patient's symptoms.[9]

There are several types of deep brain stimulation. Certain devices as Activa® or Brio™ Rechargeable IPG, delivers open-loop stimulation, which means that the pulses of the current are delivered constantly. This type of devices could be also divided into constant-voltage devices, as were the first Activa® devices and constant-current devices, which is for instance Brio™ Rechargeable IPG.[11] In contrast to open-loop systems, closed-loop systems deliver stimulation only in the case the stimulation is needed.[12] The example of the closed-loop system of deep brain stimulation could be RNS® System.[13]

Historical overview

The first reported neurosurgery was conducted in South America approximately 5000 B.C. It consists in boring of holes into the scull of patients as a treatment of neurologic and psychiatric diseases. It was believed that these diseases were caused by the maleficent spirit, who would be eliminated through the hole.[2] The first deep brain stimulation was used for the treatment of human patients in the middle of the 20th century. It was focused on mental and movement disorders. The mortality rate was high, however, and the efficient drug appeared soon after the introduction of DBS. Therefore, the method was abandoned at that time.[14] In addition, FDA required a strict regulation of medical devices since 1976. Therefore, deep brain stimulation system have to proved that they are cost-effective before their used as a treatment.[15]

The renaissance of deep brain stimulation started in late 1980s, when Alim-Louis Benabid use DBS as a treatment for Parkinson's disease and dystonia. His research was accepted better than those of his precursor, even though, there were no considerable difference in his approach. The important factor was that in the period, when he is conducted his research, the neurologists were looking for an alternative to levodopa, the drug which was used as a treatment of Parkinson's disease. They faced the fact that the drug lost its effectiveness in the long run. In addition Benabid successfully identified regions in the brain which should be stimulated.[15] DBS had been provided at humanitarian device exemption at first, but it was approved as a treatment of Parkinson's disease and essential tremor in 1997.[16] It has also pre-market approval for a treatment of dystonia,[17] epilepsy[18] and OCD[2].

Purpose

Deep brain stimulation was developed as a treatment of neurological and psychiatric diseases, in the cases when medication is unsuccessful.

Important Dates

  • about 5000 B.C. the first trephinations were conducted in South America.[2]
  • 1987 - the research on deep brain stimulation of the thalamic nucleus ventralis intermedius to treat symptoms of Parkinson's disease was published[19]
  • 1993 - deep brain stimulation of subthalamic nucleus was introduced as a treatment of Parkinson's disease.[20]
  • 1997 - deep brain stimulation was approved as a treatment of essential tremor by FDA.[7]
  • 2002 - deep brain stimulation was approved as a treatment of Parkinson's disease by FDA.[15]

Enhancement/Therapy/Treatment

Enhancement

Although DBS is primarily used in medicine, it has also certain potential in cognitive enhancement. Clement Hamani and his colleagues reported that during the surgery and DBS treatment of one of their patients, certain cognitive enhancement appeared. The patient suffered from morbid obesity and since the other attempts to reduce his weight fell or were refused, they suggested DBS. In order to affect obesity, they decided to stimulate hypothalamus, which is also linked with memory. After the stimulation of hypothalamus, patient reported an enhancement of memory. The enhancement was also proved in testing, namely the patient scored significantly better in California Verbal Learning Test and Spatial Associative Learning Test.[4]

Parkinson's disease

Parkinson's disease is the neurodegenerative disease, which is caused by loss of neurons in the substantia nigra pars compacta. These neurons produce dopamine, therefore patients suffer from the loss of dopamine. It causes tremor, postural instability and bradykinesia. Patients could be treated by levodopa or other dopaminergic drugs but these drugs have side effects in the long-term use and tend to loss their efficiency.[21] The accuracy of diagnosis of Parkinson's disease is low, thus deep brain stimulation is appropriate only for those patients, which suffer from it for more than 5 years, in order to assure that they really suffers from Parkinson's disease. Therefore, deep brain stimulation is mainly used among patients, whose medication cannot sufficiently handle with the symptoms of Parkinson's disease and the diagnosis of the disease was confirmed.[7] However, each candidate for DBS as a treatment of Parkonson's disease has to be reviewed carefully by the doctor, in order to decide that the treatment is appropriate and cost-efficient for him or her.[10] As a treatment of Parkinson's disease is usually used the stimulation of one of these three areas of brain: the thalamus, globus pallidus pars interna (GPi), or subthalamic nucleus (SNT), but the stimulation of SNT is preferred at present.[21] Breit and his colleagues claim that recently DBS turned to be the most frequently used surgical therapy for movement disorders.[10]

Essential tremor

Dystonia

Dystonia is a movement disorder, which consists in muscle contractions. The contractions usually cause twisting, repetitive movements or abnormal postures. Dystonia could be divided into primary and secondary dystonia. Primary dystonia might be inherited and it is not linked with other neurological disorder. Secondary dystonia, in contrast, could be caused by brain injury, intoxication, or drug's abuse. Secondary dystonia is further linked with other neurological sighs.[22]

Two types of stimulation have been used for a treatment of dystonia, pallidal stimulation (stimulation of GPi) and thalamic stimulation. While benefits of pallidal stimulation were documented, there are not sufficient data to claim benefit of thalamic stimulation.[23] The stimulation of GPi have positive impact mainly on primarily dystonia, in the case of secondary dystonia the responses considerably vary.[16]

Epilepsy

Obsessive-compulsive disorder

Pain

http://www.eurekalert.org/pub_releases/2016-04/uota-eso040416.php

Anorexia nervosa

http://www.thelancet.com/journals/lanpsy/article/PIIS2215-0366(17)30076-7/fulltext, https://tribune.com.pk/story/1337579/scientists-test-deep-brain-stimulation-potential-anorexia-therapy/

Bipolar

http://neurocritic.blogspot.cz/2012/01/deep-brain-stimulation-for-bipolar.html

Alzheimer's disease

http://link.springer.com/article/10.1007/s10072-015-2120-6


http://ve5kj6kj8s.scholar.serialssolutions.com/?sid=google&auinit=C&aulast=Fukaya&atitle=Deep+brain+stimulation+for+Parkinson%E2%80%99s+disease:+recent+trends+and+future+direction&id=doi:10.2176/nmc.ra.2014-0446&title=Neurologia+medico-chirurgica&volume=55&issue=5&date=2015&spage=422&issn=0470-8105

http://ve5kj6kj8s.scholar.serialssolutions.com/?sid=google&auinit=JF&aulast=Baizabal-Carvallo&atitle=The+safety+and+efficacy+of+thalamic+deep+brain+stimulation+in+essential+tremor:+10+years+and+beyond&id=pmid:24096713

Ethical & Health Issues

Discrepancy in the DBS programme - https://defeatparkinsons.com/2015/11/06/taking-a-closer-look-at-dbs-by-dr-de-leon/

the problem with sham stimulation - [21]

Public & Media Impact and Presentation

https://www.youtube.com/watch?v=7wYfafhuITA

http://www.espn.com/espn/story/_/id/8194683/davis-taylor-phinney

https://www.youtube.com/watch?v=aHxd_IIbxE4

https://www.youtube.com/watch?v=fDz6R82h6qU

https://www.youtube.com/watch?v=L_c2yI5otTM

https://www.youtube.com/watch?v=Jk0TGTdCXgQ

https://www.youtube.com/watch?v=LON36XhpdDs

http://www.medgadget.com/2013/06/a-fantastic-demonstration-of-deep-brain-stimulation-for-parkinsons.html

Public Policy

Related Technologies, Projects or Scientific Research

References

  1. ↑ 1.0 1.1 GOSSET, Nathalie, DIETZ, Nicholas. IEEE Pulse [online]. Unlocking Pain: Deep brain stimulation might be the key to easing depression and chronic pain. 2015, Mar 15. Available online at: http://pulse.embs.org/march-2015/unlocking-pain/ (Retrieved 13th April, 2017).
  2. ↑ 2.0 2.1 2.2 2.3 LOZANO, Andres. Tuning the Brain. The Scientist [online]. 2013, Oct 28. Available online at: http://www.the-scientist.com/?articles.view/articleNo/38047/title/Tuning-the-Brain/ (Retrieved 12th April, 2017).
  3. ↑ U.S. Food and Drug Administration. FDA approves brain implant to help reduce Parkinson’s disease and essential tremor symptoms. U.S. Food and Drug Administration [online]. 2015, Jun 12. Available online at: https://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm451152.htm (Retrieved 6th April, 2017).
  4. ↑ 4.0 4.1 HAMANI, Clement. et al. Memory enhancement induced by hypothalamic/fornix deep brain stimulation. Annals of Neurology, 2008, 63(1), 119–123. Doi: 10.1002/ana.21295 Available online at: http://ve5kj6kj8s.scholar.serialssolutions.com/?sid=google&auinit=C&aulast=Hamani&atitle=Memory+enhancement+induced+by+hypothalamic/fornix+deep+brain+stimulation&id=doi:10.1002/ana.21295&title=Annals+of+neurology&volume=63&issue=1&date=2008&spage=119&issn=0364-5134 (Retrieved 13th April, 2017).
  5. ↑ 5.0 5.1 5.2 5.3 NORDQVIST, Joseph. What is Deep Brain Stimulation?. MedicalNewsToday [online]. 2016, Sep 7. Available online at: http://www.medicalnewstoday.com/articles/265445.php?utm_source=TrendMD&utm_medium=cpc&utm_campaign=Medical_News_Today_TrendMD_0 (Retrieved 11th April, 2017).
  6. ↑ GILLIES, Martin J. et al. Rechargeable vs. Nonrechargeable Internal Pulse Generators in the Management of Dystonia. Neuromodulation: Technology at the Neural Interface, 2013, 16(3), 226-229. Doi: 10.1111/ner.12026 Available online at: http://onlinelibrary.wiley.com/doi/10.1111/ner.12026/full (Retrieved 11th April, 2017).
  7. ↑ 7.0 7.1 7.2 DANCE, Amber. Deep-Brain Stimulation: Decade of Surgical Relief, Not Just for PD. Alzforum [online]. 2010, May 21. Available online at: http://www.alzforum.org/news/research-news/deep-brain-stimulation-theres-still-room-improvement (Retrieved 12th April, 2017).
  8. ↑ SIRVEN, J.I. Responsive Neurostimulation. Epilepsy Foundation [online]. 2014, May. Available online at: http://www.epilepsy.com/learn/treating-seizures-and-epilepsy/devices/responsive-neurostimulation (Retrieved 13th April, 2017).
  9. ↑ 9.0 9.1 DANCE, Amber. Deep-Brain Stimulation: There’s Still Room for Improvement. Alzforum [online]. 2010, May 25. Available online at: http://www.alzforum.org/news/research-news/deep-brain-stimulation-electrode-all-occasions (Retrieved 13th April, 2017).
  10. ↑ 10.0 10.1 10.2 BREIT, Sorin et al. Deep Brain Stimulation. Cell and Tissue Research, 2004, 318(1), 275–288. Doi: 10.1007/s00441-004-0936-0 Available online at: http://link.springer.com/article/10.1007/s00441-004-0936-0 (Retrieved 13th April, 2017).
  11. ↑ PREDA, F. et al. Switching from constant voltage to constant current in deep brain stimulation: a multicenter experience of mixed implants for movement disorders. European Journal of Neurology, 2016, 23(1), 190–195. Doi:10.1111/ene.12835 Available online at: http://onlinelibrary.wiley.com/doi/10.1111/ene.12835/full (Retrieved 6th April, 2017).
  12. ↑ PICILLO, Marina, FASANO, Alfonso. Recent advances in Essential Tremor: Surgical treatment. Parkinsonism & Related Disorders, 2016, 22(1), S171–S175. DOI: 10.1016/j.parkreldis.2015.09.012 Available online at: http://www.sciencedirect.com/science/article/pii/S1353802015003879 (Retrieved 6th April, 2017).
  13. ↑ WU, C., SHARAN, A.D. Neurostimulation for the Treatment of Epilepsy: A Review of Current Surgical Interventions. Neuromodulation, 2013, 16, 10–24. Doi: 10.1111/j.1525-1403.2012.00501.x Available online at: http://onlinelibrary.wiley.com/doi/10.1111/j.1525-1403.2012.00501.x/abstract (Retrieved 13th April, 2017).
  14. ↑ SCHWALB, Jason M., HAMANI Clement. The history and future of deep brain stimulation. Neurotherapeutics. 2008, Jan. 5(1), 3–13. Doi: 10.1016/j.nurt.2007.11.003 Available online at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5084122/ (Retrieved 13th April, 2017).
  15. ↑ 15.0 15.1 15.2 GARDNER, John. A history of deep brain stimulation: Technological innovation and the role of clinical assessment tools. Social Studies of Science. 2013, Oct. 43(5), 707–728. Doi: 10.1177/0306312713483678 Available online at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3785222/#bibr79-0306312713483678 (Retrieved 13th April, 2017).
  16. ↑ 16.0 16.1 MIOCINOVIC, Svjetlana et al. History, Applications, and Mechanisms of Deep Brain Stimulation. Neurological Review. 2013, 70(2), 163-171. Doi: 10.1001/2013.jamaneurol.45 Available online at: http://jamanetwork.com/journals/jamaneurology/fullarticle/1391074 (Retrieved 19th April, 2017).
  17. ↑ University of Wisconsin Hospitals and Clinics. Neurosurgery: Deep Brain Stimulation (DBS) Frequently Asked Questions. University of Wisconsin Hospitals and Clinics [online]. 2017. Available online at: http://www.uwhealth.org/neurosurgery/deep-brain-stimulation-dbs-frequently-asked-questions/12764 (Retrieved 19th April, 2017).
  18. ↑ Business Wire. FDA Grants Premarket Approval (PMA) for the NeuroPace® RNS® System to Treat Medically Refractory Epilepsy. Business Wire [online]. 2013, Nov 14. Available online at: http://www.businesswire.com/news/home/20131114006420/en/3073855/FDA-Grants-Premarket-Approval-PMA-NeuroPace%C2%AE-RNS%C2%AE (Retrieved 19th April, 2017).
  19. ↑ BENABID A.L. et al. Combined (Thalamotomy and Stimulation) Stereotactic Surgery of the VIM Thalamic Nucleus for Bilateral Parkinson Disease. Appl Neurophysiol, 1987, 50, 344–346 Doi: 10.1159/000100803 Available online at: https://www.karger.com/Article/Abstract/100803 (Retrieved 12th April, 2017).
  20. ↑ BENABID A.L. et al. Acute and long-term effects of subthalamic nucleus stimulation in Parkinson’s disease. Stereotact Funct Neurosurg, 1994, 62, 76–84. Doi: 10.1159/000098600 Available online at: https://www.karger.com/Article/Abstract/98600 (Retrieved 12th April, 2017).
  21. ↑ 21.0 21.1 21.2 WILLIAMS, Adrian et al. Deep brain stimulation plus best medical therapy versus best medical therapy alone for advanced Parkinson’s disease(PD SURG trial): a randomised, open-label trial. Lancet Neurology. 2010, 9(6), 581–91. Doi: 10.1016/S1474-4422(10)70093-4 Available online at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2874872/ (Retrieved 19th April, 2017).
  22. ↑ ANDREWS, Caroline et al. Which patients with dystonia benefit from deep brain stimulation? A metaregression of individual patient outcomes. Journal of Neurology, Neurosurgery and Psychiatry, 2010, 81(12), 1383-1389. Doi: 10.1136/jnnp.2010.207993 Available online at: http://jnnp.bmj.com/content/81/12/1383.long (Retrieved 19th April, 2017).
  23. ↑ TAGLIATI, Michele et al. Long-Term management of DBS in dystonia: Response to stimulation, adverse events, battery changes, and special considerations. Movement disorders. 2011, 26(1), 54-62. Doi: 10.1002/mds.23535 Available online at: http://onlinelibrary.wiley.com/doi/10.1002/mds.23535/abstract (Retrieved 19th April, 2017).
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