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TNS is not yet been approven by FDA. It has been studied in animal and pilot clinical trials. But it has not yet been sufficiently corroborated, that TNS is effective to treat epilepsy, based on relativelly small scale of the trials.<ref name="Trigeminal Nerve Stimulation May Not Be Effective">PACK, A.M. Trigeminal Nerve Stimulation May Not Be Effective for the Treatment of Refractory Partial Seizures. Epilepsy Currents. 2013, Vol. 13, No. 4, pp. 164–165.</ref>
DBS treatment is stimulation of the different areas of central nervous system. Most extensively has been studied the stimulation of the anterior nucleus of the thalamus. That The DBS stimulation has been approved first by European Union (Conformité Européenne, CE)for company Medtronic in 2013 <ref name="Medtronic Receives European CE Mark Approval">Medtronic. Medtronic Receives European CE Mark Approval for Deep Brain Stimulation Therapy for Refractory Epilepsy. Medtronic, Inc. [online]. 2010. Available online at: http://newsroom.medtronic.com/phoenix.zhtml?c=251324&p=irol-newsArticle&ID=1773303 (Retrieved 5.12.2016)</ref> , and than by FDA in 2013 for treatment of epilepsy (under the FDAs Humanitarian Device Exception)<ref name="Deep Brain Stimulation: Expanding Applications">TEKRIWAL, A., BALTUCH, G. Deep Brain Stimulation: Expanding Applications. Neurol Med Chir, Tokyo, 2015, Vol. 55, No. 12, pp. 861–877.</ref>. The other areas of the stimulation are, for example the cerebellum or the hippocampus. Effectiveness of the stimulation in the anterior nucleus is estimated on 40% reduction seizures.<ref name="Neurostimulation for the Treatment of Epilepsy"/>
The RNS System is on the other hand based on closed-loop stimulation, which provide stimulation only if triggered by early seizure activity. However the above meantioned systems of stimulation provide stimulation constantly, regardless of neuronal activity. So the RNS System has less adverse effect than the rest.<ref name="Neurostimulation for the Treatment of Epilepsy"/>
