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→Principle: update
Electrodes should stimulate clusters of afferent senzoric nerves and this should trigger inhibition of pain in brainstem. Inhibition comes up due to cascade neurotransmitter release. This descending process starts in periaqueductal gray matter, continuing to medulla and then into spinal cord (its dorsal horn)<ref>Introducing Quell™, a 100% drug free technology proven to fight pain: https://www.quellrelief.com/files/Quell%20HCP%201%20page%20(3).pdf</ref>. Within-body-produced opioids, enkephalins, causes inhibition of pain signal transmission, while activate δ-opioid receptors.
Company also claims, that Quell is as twice stronger as previous TENS pain relieving products, thus it doesn't have to be used locally, but only on an upper calf.
[[File:Quell principle.jpeg|thumbnail| Official webpage depictures the process of how pain is blocked in medulla<ref>Introducing Quell, a 100% drug free technology proven to fight pain: https://www.quellrelief.com/files/Quell%20HCP%201%20page%20(3).pdf</ref>.]]
