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For easier control it is possible to download Quell application for iOS<ref>Quell relief application available to download: https://itunes.apple.com/app/quell-relief/id972079954</ref> or Android<ref>Quell relief application available to download on GooglePlay: https://play.google.com/store/apps/details?id=com.neurometrix.quell</ref>. Company offers also [https://www.quellrelief.com/quell-user registration] of individual user's device, which will allow company databasis to collect measured data about user and treatment process (this registration is optional, though).
Mechanism of the treatment lies in the following process: in electrode that stimulates clusters of afferent senzoric nerves and this should trigger inhibition of pain in brainstem. Inhibition comes up due to cascade neurotransmitter release. This descending process starts in periaqueductal gray matter, continuing to medulla and then into spinal cord (its dorsal horn).<ref>Introducing Quell™, a 100% drug free technology proven to fight pain: https://www.quellrelief.com/files/Quell%20HCP%201%20page%20(3).pdf</ref> Within-body-produced opioids, enkephalins, causes inhibition of pain signal transmission, while activate δ-opioid receptors. The described process should be the core of reason why it is cleared as 100% drug free.More detailed description regarding TENS technology (not Quell in particular) is available in Johnson's book Transcutaneous Electrical Nerve Stimulation.<ref>Johnson, Mark I., Transcutaneous Electrical Nerve Stimulation (TENS): Research to support clinical practice, Oxford University Press, 2014, p. 272</ref>
Company also claims, that Quell is as twice stronger as previous TENS pain relieving products, thus it doesn't have to be used locally, but only on an upper calf.<ref>NeuroMetrix Investor statement: http://investor.neurometrix.com/releasedetail.cfm?releaseid=923300, December 15, 2015</ref> Much detailed description regarding TENS technology (not Quell in particular) is found in Johnson's book Transcutaneous Electrical Nerve Stimulation.<ref>Johnson, Mark I., Transcutaneous Electrical Nerve Stimulation (TENS): Research to support clinical practice, Oxford University Press, 2014, p. 272</ref>
[[File:Quell principle.jpeg|thumbnail| Official webpage depictures the process of how pain is blocked in medulla.<ref>Introducing Quell, a 100% drug free technology proven to fight pain: https://www.quellrelief.com/files/Quell%20HCP%201%20page%20(3).pdf</ref>]]
