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RNS® System (hereinafter referred to as RNS System) is medical device for epilepsy treatment.<ref name="neuropaceAbout_the_technology">NeuroPace. About the technology. NeuroPace, Inc. [online]. © 2016. Available online at: http://www.neuropace.com/the-rns-system/ (Retrieved 4.11.2016)</ref> It can monitor and stimulate brain activity, for it is [[Deep brain stimulation|deep brain stimulation ]] device. It is manufactured by privately held company named NeuroPace, which is located in Montain View, California.<ref name="BusinessWirePhoenixConference">NeuroPace RNS® System Honored With Prestigious Award At The 22nd Annual Phoenix Conference. Business Wire: A Berkshire Hathaway Company [online]. 2015, Nov 4. Available online at: http://www.businesswire.com/news/home/20151104005381/en/NeuroPace-RNS%C2%AESystem-Honored-Prestigious-Award-22nd (Retrieved 4.11.2016)</ref> The therapy with RNS System consists in reducing the frequency of seizures in individuals<ref name="NeuropaceSystemUserManual"/>, who have partial-onset, medically refractory (drug resistant) epilepsy.<ref name="NCBI">THOMAS, G.P., JOBST, B.C. Critical review of the responsive neurostimulator system for epilepsy. The National Center for Biotechnology Information [online]. 2015, Oct 1. Available online at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4598207/ (Retrieved 4.11.2016)</ref> Those patients are treated with the RNS System, when they have no more than two epileptogenic foci (epileptogenic focus is the source or starting point of the seizures) and are resistant to more than two antiepileptic medications. The RNS System is thus only for medical prescription.

There exist several possible treatment for epilepsy on the basis of [[Deep brain stimulation|deep brain stimulation]]: vagus nerve stimulation (VNS), trigeminal nerve stimulation (TNS), deep brain stimulation (DBS), and closed-loop stimulation system (RNS System).<ref name="Neurostimulation for the Treatment of Epilepsy"/>